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KMID : 0895820090190010091
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Journal of Oriental Rehabilitation Medicine
2009 Volume.19 No. 1 p.91 ~ p.102
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Anti-Cancer Effects of Salvia Miltiorrhiza, Carydalis Turtschaminovii, Reynoutria Elliptica Herbal Acupuncture on Solid Tumor of Rats induced by Injection of RK3E-ras Cells
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Park Soo-Gon
Shin Mi-Suk
Choi Jin-Bong
Kim Sun-Jong
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Abstract
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Objectives :The present study was carried out investigate the anti-cancer effect of Salvia miltiorrhiza, Carydalis turtschaminovii and Reynoutria elliptica herbal acupuncture on solid tumor of rats induced by injection of RK3E-ras cells.
Methods :RK3E-ras cells were injected on the right lumbar region of rats. After 1 weeks, the experimental rats were divided into four groups : Control group, Salvia miltiorrhiza herbal acupuncture group(SM), Carydalis turtschaminovii herbal acupuncture group(CT), Reynoutria elliptica herbal acupuncture group(RE). And we investigated the weight and size of tumor tissue, gross anatomy, histological and PCNA immunohistochemical study, hepatic and renal metastasis for tumor of each group.
Results :1. In the weight of tumor tissue assessment, SM and CT’s weight of tumor tissue was decreased. 2. In the size of tumor tissue assessment, SM was smaller than any other group. 3. In the histological observation, SM’s formation of tunica fibrosa that surround the tumor cell was obvious and vasculature that developes circumference of tumor cell was not observed, and density of tumor cell was very low. 4. In the PCNA immunohistochemical study, Control group, SM, RE showed strong immune response in the central site of tumor tissue. 5. In observation of liver and kidney tissue, we were not able to observe tumor cell in the SM.
Conclusion :Consequently, SM and CT showed a inhibition of growth and metastasis.
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KEYWORD
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Salvia miltiorrhiza, Carydalis turtschaminovii, Reynoutria elliptica, Herbal acupuncture, RK3E-ras cells, Solid tumor, Proliferating cell nuclear antigen(PCNA) immunohistochemical study
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